- TRAC is a relevant orthotopic integration anchor
- Matched architecture comparison is defined
- Core locus evidence is source-linked
- Genome integrity requires structural assays
DECISION / GATE 01TF-P01
A decision packet shows what is known, what is not, and what happens next.
The platform will not collapse unresolved safety evidence into a reassuring average score.
Current recommendation
42/100Do not advance yet
Keep TRAC knock-in as the lead architecture. Resolve donor geometry, matched functional performance and cross-reactivity before locking the construct.
- Expression control advantage
- Reduced receptor competition
- Predicted pMHC geometry
- Donor junction geometry
- Near-self cross-reactivity
- Matched functional response