All records82 Karen input4 Phase 1 inputs41 Patent review14 Phase 1 evidence path Source element → sequence and rights → ON and OFF context → model prior → matched wet-lab assay Public evidence sets priors · internal measurements decide ranking Select all Add to worklist Export metadata 82 shown
Material Theme How we use it Access R-008 · 2026 Karen · Promoter–Enhancer Constructs ReferenceCollaborator input Ten proposed Phase 1 constructs, sequence sources and Karen shortlist Phase 1 R-009 · 2026 Karen · TCR beta promoter and enhancers ReferenceCollaborator input Exact ICOS, CD3D, TCRβ enhancer and Vβ8.1 promoter sequence notes Phase 1 R-010 · 2026 Karen · Patents related to T-cell promoter ReferenceCollaborator input Seven patent leads received for identifier and claim-scope validation Phase 1 R-011 · 2026 Karen · Yi Lin VV169 in vivo CAR-T · 13 Oct ReferenceCollaborator input Source-reported CD3 delivery, Lck promoter and reversed cassette comparator · exact sequences and matched OFF evidence pending Phase 1 P-001 · 1989 Winoto & Baltimore · TCRα enhancer PaperRegulatory biology Foundational definition of the Eα enhancer Phase 1 P-002 · 2015 Delgado · Eα in mature T cells PaperRegulatory biology Separates developmental locus control from mature T-cell behavior Phase 1 P-003 · 2025 Schönberg · Tα2 CRISPR screen PaperRegulatory biology Human mature T-cell evidence for functional cis-regulatory elements Phase 1 P-004 · 2021 Moosmann · Orthotopic TCR replacement protocol PaperCell engineering Executable protocol for orthotopic receptor replacement Platform context P-005 · 2023 Foy · Precision TCR replacement PaperCell engineering Clinical translation and manufacturing context for personalized neoTCRs Platform context P-006 · 2026 Nyberg · In vivo TRAC engineering PaperCell engineering Preclinical in vivo delivery and TRAC engineering reference Platform context P-007 · 2025 Cullot · DNA-PK inhibition and genomic alterations PaperGenome safety Large-deletion and structural-variant boundary for HDR enhancement Platform context P-008 · 2021 Enformer PaperRegulatory AI Long-context regulatory sequence prior Phase 1 P-009 · 2025 Borzoi PaperRegulatory AI Long-context RNA and regulatory output prediction Phase 1 P-010 · 2026 AlphaGenome PaperRegulatory AI One-megabase multimodal regulatory prediction prior Phase 1 P-011 · 2021 NetTCR-2.0 PaperTCR specificity Paired-chain sequence specificity baseline Platform context P-012 · 2023 TCRmodel2 PaperTCR structure TCR–pMHC structural hypothesis generation Platform context P-013 · 2024 HeteroTCR PaperTCR specificity Heterogeneous graph formulation for receptor specificity Platform context P-014 · 2024 TCR–pMHC server comparison PaperModel audit Independent comparison of structural servers and failure modes Platform context P-015 · 2025 TCRBuilder2+ PaperTCR structure TCR structure and structural-diversity modeling Platform context P-016 · 2025 TCRT5 PaperTCR generation Conditional receptor generation under sparse unseen-epitope evidence Platform context P-017 · 2025 UniPMT PaperTCR specificity Multitask peptide–MHC–TCR representation learning Platform context P-018 · 2026 Structure-based TCR–pMHC prediction PaperTCR specificity Tests structural generalization beyond sequence similarity Platform context P-019 · 2021 tcrdist3 PaperRepertoire Distance-based repertoire analysis and meta-clonotypes Platform context P-020 · 2024 Multimodal TCR and scRNA model PaperCell state Links receptor identity with transcriptional cell state Platform context P-021 · 2024 SCEPTR PaperTCR representation Compact contrastive receptor representation Platform context P-022 · 2024 TCR-BERT PaperTCR representation Self-supervised receptor language modeling Platform context P-023 · 2025 ePytope-TCR benchmark PaperModel audit Unified evaluation of general and categorical predictors Platform context P-024 · 2026 TCRBinder PaperTCR specificity Paired αβ plus peptide and HLA-aware fusion model Platform context P-025 · 2026 pMTnet-omni PaperTCR specificity Pan-MHC and cross-species class-I and class-II extension Platform context P-026 · 2026 ImmSET PaperTCR specificity Scalable set-transformer specificity model Platform context P-027 · 2023 iSynPro · Context-specific synthetic T-cell promoters PaperSynthetic regulation Combinatorial activation-responsive promoter grammar Phase 1 P-028 · 2024 Gosai · Machine-guided cell-type-targeting CREs PaperSynthetic regulation Model-guided design with a 36,000-candidate MPRA Phase 1 P-029 · 2024 Taskiran · Cell-type-directed synthetic enhancers PaperSynthetic regulation Deep-learning-directed enhancer design and motif grammar Phase 1 P-030 · 2019 SPECS · Cell-state-specific synthetic promoters PaperExpression control High-throughput library and learning-loop template Phase 1 P-031 · 2020 Promoter choice in CAR-T PaperExpression control Reference comparison of EF1α, CMV, hPGK and RPBSA Phase 1 P-032 · 2020 dLck and CD3δ T-cell promoters PaperExpression control Lineage-selective promoter benchmark in a lentiviral system Phase 1 P-033 · 2022 Physiological WAS-promoter CAR-T PaperExpression control Physiological expression and tonic-signaling comparator Phase 1 P-034 · 2025 NR4A2 endogenous rewiring PaperExpression control High-bar comparator for tumor-restricted payload expression Phase 1 P-035 · 2025 SPECIFIC · T-cell-state-responsive promoters PaperSynthetic regulation ATAC, motif and machine-learning workflow for T-cell state control Phase 1 P-036 · 2026 CREsted PaperRegulatory AI Trainable sequence-to-accessibility and enhancer-design backbone Phase 1 L-001 · 2012 Shih · CTCF and cohesin Tcra chromatin hub PaperRegulatory biology Three-dimensional locus organization reference Platform context L-002 · 2020 Belhocine · Human thymic development atlas PaperRegulatory biology RNA and chromatin accessibility across human thymic development Platform context L-003 · 2017 Eyquem · CAR integration into TRAC PaperCell engineering Foundational rationale for TRAC-linked expression control Platform context L-004 · 2018 Roth · Non-viral genome targeting PaperCell engineering Non-viral CRISPR targeted-integration foundation Platform context L-005 · 2019 Schober · Orthotopic TCR replacement PaperCell engineering Orthotopic replacement architecture Platform context L-006 · 2023 Tsuchida · Cas9-induced chromosome loss PaperGenome safety Chromosome-loss risk and mitigation Platform context L-007 · 2001 Human CD2 LCR in lentiviral vectors PaperExpression control Position-independent expression and vector-cost benchmark Phase 1 L-008 · 2011 T-cell-specific promoter comparison PaperExpression control Legacy Vβ6.7, Vβ5.1, Luria and Delta comparison Phase 1 L-009 · 2026 Minimal NR4A1 promoter for auto-inducible CAR expression PaperExpression control Native activation-responsive comparator Phase 1 L-010 · 2026 PanPep reusability report PaperModel audit External reusability and generalization check Platform context L-011 · 2021 pMTnet PaperTCR specificity Early deep-learning peptide–MHC–TCR predictor Platform context L-012 · 2026 TCRTransBench PaperModel audit Post-2025 transfer and benchmark watch item Platform context L-013 · 2026 AI for T- and B-cell receptor modeling review PaperReview Cross-field model taxonomy and frontier watch Platform context L-014 · 2026 Cell-based kinetic framework for TCR specificity PaperTCR function Kinetic and activation-aware specificity evidence Platform context PT-001 · 2023 US11851649B2 · iSynPro PatentActivation circuit Response-element grammar and positive controls Phase 1 PT-002 · 2024 US20240043868A1 · B2M-derived physiological promoters PatentPhysiological promoter Compact physiological-expression benchmark Phase 1 PT-003 · 2024 WO2024223701A1 · CD4-locus synthetic promoter PatentLineage promoter T-cell lineage-selective benchmark and FTO flag Phase 1 PT-004 · 2025 WO2025003526A1 · Viral vector and producer cell PatentVector production Identifier mismatch found during Karen intake · do not use as promoter evidence Platform context PT-005 · 2025 US20250152709A1 · CD3-targeted lentiviral regulation PatentTargeting and gating Promoter, miRNA and negative-gate design axes Phase 1 PT-006 · 2024 US20240352481A1 · NFAT reporter system PatentActivation circuit NFAT response-element and minimal-promoter control Phase 1 PT-007 · 2023 WO2023225482A2 · NR4A1 response elements PatentActivation circuit NIR and NurRE response-element comparator Phase 1 PT-008 · 2024 WO2024241419A1 · NFAT and NR4A promoter PatentActivation circuit Composite activation-circuit benchmark and FTO flag Phase 1 PT-009 · 2021 US20210015869A1 · T cells expressing a recombinant receptor PatentEndogenous-locus engineering Relevant architecture lead · not general synthetic-promoter evidence Phase 1 PT-010 · 2019 WO2019157454A1 · Non-HLA restricted T cell receptors PatentReceptor engineering Adjacent receptor and TRAC architecture · outside promoter sequence scope Platform context PT-011 · 2019 WO2019210078A1 · FOXP3 in gene-edited T cells PatentCell engineering Adjacent endogenous-locus cell engineering · not generic promoter evidence Platform context PT-012 · 2017 WO2017180989A2 · Transgenic T cell and CAR-T compositions PatentEndogenous T-cell promoters Relevant disclosure for transgenes controlled by TCRα, TCRβ and CD3 promoters Phase 1 PT-013 · 2020 US10851388B2 · Tissue-selective transgene expression PatentConditional expression Adjacent recombinase-gated system · not TRAC promoter hijacking Platform context PT-014 · 2020 WO2020264039A1 · Artificial antigen-specific immunoregulatory T cells PatentTherapeutic cells Adjacent therapeutic-cell disclosure · promoter relevance not established Platform context DS-001 · Live DICE DatasetImmune-cell atlas Normal immune-cell ON and OFF baseline Phase 1 DS-002 · Live ENCODE SCREEN DatasetRegulatory annotation cCRE annotation, context tracks and sequence flags Phase 1 DS-003 · 2022 GSE179593 DatasetT-cell chromatin ATAC prior across 217 samples and 14 T-cell subsets Phase 1 DS-004 · 2020 GSE153379 DatasetMalignant OFF atlas ATAC counter-screen for normal plasma and multiple myeloma states Phase 1 DS-005 · 2020 GSE153380 DatasetMalignant OFF atlas Matched RNA-seq and TF-state interpretation Phase 1 DS-006 · 2020 GSE153381 DatasetCohort provenance Cross-modal linkage for the matched myeloma studies Phase 1 DS-007 · Live MMRF CoMMpass DatasetMyeloma cohort External malignant-state prevalence check Phase 1 R-001 · 2026 TCRForge model registry ReferenceStructured registry 107 systems with principles, invocation, training and workflow placement Platform context R-002 · 2026 Regulatory evidence seed registry ReferenceStructured registry Machine-readable source, sequence availability and limitation map Phase 1 R-003 · 2026 mu promoter-design workshop ReferenceInternal evidence First-loop objective, assay assumptions and collaboration contract Phase 1 R-004 · 2026 TCRForge concept and platform deck ReferencePlatform guide Science foundation, model landscape and product position Platform context R-005 · Live TCREpitopeBenchmark ReferenceExternal benchmark Reproducible TCR–epitope evaluation reference Platform context R-006 · Live IMMREP25 blinded challenge ReferenceExternal benchmark Blinded specificity-prediction challenge Platform context R-007 · Live ImmuneCLIP repository ReferenceModel repository Reusable receptor representation implementation Platform context
82 materials shown Library updated 13 Oct 2026 Scientific role Ten proposed Phase 1 constructs, sequence sources and Karen shortlist
Evidence state
Program use Active Phase 1 input
Provenance Internal working record Admission boundary This record informs a hypothesis, comparator or model prior · matched experiments remain the decision gate
Open gaps Sequence-level patent extraction Global family and FTO review Locked core promoter Matched normal and malignant OFF panel