LOCUS / TRA–TRDTF-P01

TRA/TRD locus atlas

Inspect the engineered allele and separate established locus biology from context-dependent transfer assumptions

Apply to construct
GRCh38 · chr14Rearranged primary T-cell context
EstablishedContext-dependentUnresolved
21.60 Mb22.90 Mb
Selected element

TRAC exon 1

Knock-in anchor

An important endogenous-control comparison arm. Keep it separate from portable synthetic regulatory cassettes.

18linked evidence objectsOpen evidence
What the model can do

Rank candidate sequence perturbations

Enformer, Borzoi and AlphaGenome provide long-context priors for variant and track effects.

What must stay experimental

Calibrate the engineered TRAC allele

Rearrangement, donor insertion and mature primary-T-cell state are outside the validated zero-shot domain.