TCRForge/Locus atlas
LOCUS / TRA–TRDTF-P01

Inspect the engineered allele, not an isolated promoter fragment.

The regulatory atlas separates established locus biology from context-dependent transfer assumptions.

Apply to construct
GRCh38 · chr14Rearranged primary T-cell context
EstablishedContext-dependentUnresolved
21.60 Mb22.90 Mb
Selected element

TRAC exon 1

Knock-in anchor

The lighthouse integration anchor. Design review must connect junction geometry, expression control and receptor competition.

18linked evidence objectsOpen evidence
What the model can do

Rank candidate sequence perturbations

Enformer, Borzoi and AlphaGenome provide long-context priors for variant and track effects.

What must stay experimental

Calibrate the engineered TRAC allele

Rearrangement, donor insertion and mature primary-T-cell state are outside the validated zero-shot domain.