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Frame
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Evidence
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Decision
EVIDENCE / CLAIMS
TF-P01
Every conclusion has a source, context boundary and confidence.
Evidence is stored as decision-ready claims—not a pile of PDFs.
Open scientific primer
All
Regulation
Editing
Specificity
Structure
Translation
6 / 6 claims
CLM-001
Regulation
Eα is a distal enhancer, not a portable standalone TCRα promoter.
6 sources
+
CLM-002
Editing
Junction success alone cannot exclude structural variants or unintended integrations.
4 sources
+
CLM-003
Specificity
Paired αβ and HLA-aware models are better aligned to biology than β-only scorers.
12 sources
+
CLM-004
Structure
Complex prediction can test geometry and clashes, but not prove binding or function.
8 sources
+
CLM-005
Translation
TRAC knock-in is the best first workflow because it links locus, construct, receptor and cell phenotype.
9 sources
+
CLM-006
Regulation
General genome models can rank engineered TRAC regulatory designs without local calibration.
3 sources
+