TCRForge/Programs
PROGRAM / 01TF-P01

Promoter & enhancer program

jacky and mu work through one specificity-first loop: collect promoter and enhancer evidence, build combinations, predict performance, run wet-lab tests and learn from every result

Read operating model
Decision to makeCandidate batch lock

Which core-promoter and enhancer combination preserves high CAR expression in T cells while preventing leakage in malignant plasma or B cells?

The first cycle starts from validated regulatory elements and a fixed core-promoter context; de novo sequence generation remains a later gated track

Dual objective definedAssay context incomplete
Program objects

One decision, five connected evidence domains

Inspect all evidence
01Evidence intakePapers · patents · internal rationale

26 sources structured

02Enhancer librarymu + joint discovery

Admission active

03Combination spaceEnhancer × core promoter

12 draft designs

04Wet-lab handoffDecision packet to mu

Assay contract drafted

05Learning loopPrediction ↔ measurement

Schema drafted

Recommended next action

Lock the first 10–30 construct batch and its quantitative assay contract

Open promoter & enhancer design