PROGRAM / 01TF-P01

TCR engineering program

Current objective: compare receptor, locus, edit and cell architectures as one reconstructable system.

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Decision to makeArchitecture selection

Does TRAC-targeted integration preserve useful expression control while reducing receptor competition?

The comparison is locked to primary human T cells under matched activation, manufacturing and assay conditions.

3 criteria defined2 blocking assumptions
Program objects

One decision, five connected evidence domains

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Recommended next action

Lock the comparative experiment before optimizing any single construct.

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